Dr. Amanda Ramer-Tait
B.S., Biochemistry, Western Kentucky University
Ph.D., Immunobiology, Iowa State University
Post Doc, Immunology, Microbiology and Parasitology, Iowa State University
355 Food Industry Complex
Lincoln, NE 68583-0919
Teaching and/or Extension Activities:
Advanced Topics in Immunology, Functional Foods and Nutraceuticals, and Gastrointestinal Microbiology
Research interests in the Ramer-Tait laboratory center on the dynamic interactions between the mucosal immune system and intestinal microbial communities. Current research projects are aimed at understanding how host-microbial interactions in the gastrointestinal tract contribute to the pathogenesis of chronic, inflammatory diseases, including inflammatory bowel diseases and obesity. We are also intensively involved in research concerning the interactions among diet, the gut microbiota, and the immunological and metabolic health of the host. To study these complex relationships in vivo, we employ conventional flora, germ-free, and defined microbial community mouse model systems. We utilize approaches spanning the disciplines of cell biology, microbiology, and immunology to mechanistically interrogate the regulation of gastrointestinal homeostasis and inflammation.
Five Selected Publications:
• Huntimer L, Wilson Welder JH, Ross K, Carrillo-Conde B, Pruisner L, Narasimhan B, Wannemuehler MJ, Ramer-Tait AE. Single immunization with a suboptimal antigen dose encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses. 2013. J Biomed Mater Res Part B. 101B:91–98.
• Overstreet AMC, Ramer-Tait AE, Jergens AE and Wannemuehler MJ (2012). The Role of the Microbiota in Gastrointestinal Health and Disease, Inflammatory Bowel Disease, Imre Szabo (Ed.), ISBN: 978-953-51-0879-5, InTech.
• Liu Z, Ramer-Tait AE, Henderson AL, Demirkale CY, Nettleton D, Wang C, Hostetter JM, Jergens AE, Wannemuehler MJ. 2011. Helicobacter bilis colonization enhances susceptibility to typhlocolitis following an inflammatory trigger. Dig Dis Sci. 6(10):2838-48.
• Ramer-Tait AE, Lei SM, Bellaire BH, Beetham JK. Differential surface deposition of complement proteins on logarithmic and stationary phase Leishmania chagasi promastigotes. 2012. J Parasitol. 98(6):1109-16.
• Chavez-Santoscoy A, Roychoudhury R, Pohl NLB, Wannemuehler MJ, Narasimhan B and Ramer-Tait AE. 2012. Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using pathogen-like amphiphilic polyanhydride nanoparticles. Biomaterials. 33(18):4762-72.